美国当地时间5月30日，雅虎、US Press Association、The Morning News等众多美国媒体转载发布霍普金斯大学医学院综合癌症中心肺癌和衰老项目首席科学家张春雨博士最新研究成果《Miraculous Small Molecules - One Step Further towards Helping Cancer Prevention and Healthy Longevity》新闻，译文如下：
癌症号称死亡之症，人一旦得癌，就像被判了“死缓”，剩下的日子屈指可数。为攻克这一难题，人类一直在进行研究。近日，华裔科学家张春雨博士领导的团队实现重大突破，发现一种新型的转录激活信号通路，可以在癌细胞和正常细胞中，恢复表达兼具抗癌和延缓衰老功效的抑癌蛋白，并将其研究成果转化为膳食补充剂，造福人类。
华裔科学家带来防癌抗衰重大发现
世界卫生组织发布的《世界癌症报告》显示，癌症是全球第二大死因，同时40%的癌症是可预防的。“癌症最大的危险因素是年龄，”张春雨指出。
随着科技的发达和医疗的进步，人类平均寿命逐年增加。人口老龄化日趋严重，加之现代人久坐少动的生活方式、高强度的工作压力、不健康的饮食习惯、不尽人意的生存环境等多种因素，加速人类身体机能衰退，各类慢性疾病尤其是癌症的发病率居高不下。如何科学地延长健康寿命提高生活质量，成为当下最迫切的研究课题。
霍普金斯大学医学院综合癌症中心肺癌和衰老项目首席科学家张春雨博士
作为美国霍普金斯大学医学院综合癌症中心肺癌和衰老项目首席科学家，张春雨博士曾在耶鲁、哈佛、国立癌症研究所、拉芙蕾丝呼吸研究所等美国顶级名校和研究机构工作，在“生命时钟”端粒及端粒酶，Werner早衰蛋白与DNA聚合酶，核编码线粒体长寿突变蛋白，老化过程中慢性炎症、肥胖和癌变生物标记物FAT10，免疫调节因子基因表达和组织定位，癌症与衰老关键信号通路PI3K/Akt/mTOR及其抑制剂，肺癌发生过程中基因表达改变与化疗抗性和预后生存，香烟提取物对气道上皮细胞的DNA损伤，NOXA对肺部炎症缓解的分子机制等方面做出了国际领先的研究成果。相关论文在国际顶级期刊及核心专业杂志发表，包括《细胞》、《美国科学院院刊》、《自然》旗下刊物等。
张春雨博士及其研究团队通过对肿瘤抑制基因RhoB的表达和功能研究，在蛋白水平证明其在维护呼吸系统正常形态和功能中发挥重要作用。他们首次发现，在癌症演化和机体老化过程中，被多种表观遗传学机制下调的肿瘤抑制基因RhoB的高效转录激活的信号通路和分子机制，进而构建了世界上独有的双荧光素单分子载体，并建立了高通量药物筛选系统和创立非侵入肿瘤药物图像实时反应动物模型。此外，该团队还利用该系统从国立癌症研究所多样性小分子库中筛选出新的抗癌小分子，在肺癌、脑瘤和横纹肌肉瘤等多种癌细胞中持续高效诱导肿瘤抑制基因RhoB的蛋白表达，抑制癌细胞增殖、迁移并诱导其凋亡，而没有过多的细胞毒性。
张春雨博士根据这个发现，科学地配置植物营养素，在抑制癌细胞增殖、迁移和促使其死亡的同时，能够保护正常细胞、延长机体寿命。这一领先的科研结果证明，通过膳食干预不仅可以有效抑制皮肤炎症、延缓皮毛老化，还能显著减少烟草致癌物诱导的肺癌的发生、发展。
新型膳食补充剂防癌抗衰造福人类
根据以上研究成果，张春雨及其团队成功研发出含有神经酰胺、姜黄素和 EGCG 关键成分的膳食补充剂，并将相关技术向美国专利商标局提交了专利申请。同时为加速成果转化，张春雨博士在美国马里兰州设立盛优生命科技股份有限公司SanuLifeInc，着重研发基于科学的健康管理、生物医药和修身益智性能产品，整合优质资源及最前瞻技术为用户提供一站式、定制化、智慧型身心合一的精准健康服务。
该公司的ROVIDIUM诺威锭系列产品，利用天然存在于植物中的成分，肿瘤抑制基因RhoB在正常细胞演变成癌细胞过程中下调的特点，及其与细胞内源抗氧化、抗炎症和抗纤维化的长寿转录因子Nrf2在正常细胞中通过RhoB诱导的另一肿瘤抑制基因p21产生的协同作用，配制出科学、安全、有效的膳食补充剂，重新恢复在呼吸系统老化、骨骼肌肉衰退、以及细胞癌变过程中不断被表观遗传学下调的内源RhoB，并通过p21活化Nrf2，稳定基因组，保护细胞，防止癌变，以期延缓衰老、防癌增寿。
MiraculousSmall Molecules—One Step Further towards Helping Cancer Prevention and Healthy Longevity
Cancer is said to be a disease of death. Once a person has cancer, it is like being sentenced to "deathwith reprieve." The remaining days are few. For long, human beings have been conducting researchto overcome cancer. Recently, the team led by Dr. Zhang Chunyu, an American Chinese scientist, has made a major breakthrough and discovered a novel transcriptional activation pathway that can restore the expression of a tumor suppressor protein that combines both anti-cancer and anti-aging effects in cancer cells and normal cells. Based on the research results the team produceda dietary supplement for the benefit of mankind.
An American Chinese Scientist BringsMajor Discoveries of Cancer Prevention andAnti-agingResearch
According to the World Cancer Report released by the World Health Organization, cancer is the second leading cause of death in the world, while 40% of cancers are preventable. "The biggest risk factor for cancer is age," Zhang Chunyu pointed out.
With the development of science and technology and the advancement of medical care, the average life expectancy of human beings has increased year by year. The aging of the population has become increasingly serious, coupled with the modernsedentarylifestyle, high-intensity work pressure, unhealthy eating habits, unsatisfactory living environment and other factors. These challenges haveacceleratedthe decline of human physical function, and various types of chronic diseases, especially the incidence of cancer remains high. How to scientifically prolong healthy lifespan and improve quality of life has become the most pressing research topic of the moment.
As Principal Investigator of the Lung Cancer and Aging Program at the Sidney KimmelComprehensive Cancer Center of the Hopkins University School of Medicine, Dr. Zhang Chunyu has worked at Yale, Harvard, National Cancer Institute, Lovelace RespiratoryResearch Institute and other top-notch universities and research institutes in the United States. He has produced a number ofinternationally leading research results inthe fields of “Clock of Life"telomere and telomerase; Werner premature aging protein and DNA polymerase; nuclear encodedmitochondrial longevity mutant protein;aging-associated chronic inflammation, obesity and cancer biomarker FAT10; immunoregulatory factor gene expression and tissue localization;the key signal pathway of PI3K/Akt/mTOR for cancer and aging and its inhibitors; gene expression changes during lung cancer progression and chemotherapy resistance and prognosis survival; DNA damage from cigarette smoking extracts on airway epithelial cells; molecular mechanism of NOXA on pulmonary inflammation remission, etc.. Relevant articles have been published in the international top journals and core specialized magazines, including Cell, Proceedings of the National Academy of Sciencesand Naturepublications.
Dr. Zhang Chunyu and his team studied the expression and function of the tumor suppressor gene RhoB to prove that it plays an important role in maintaining the normal morphology and function of the respiratory system at the protein level. For the first time, they discovered that in the process of cancer evolution and aging, the signaling pathways and molecular mechanisms of efficient transcriptional activation of the tumor suppressor gene RhoB, which are down-regulated by various epigenetic mechanisms, have led to the construction of a unique dual-luciferase single vector in the world. The research team also, establisheda high-throughput drug screening system, and animal models for real-time monitoring anti-tumor drug response. In addition, the team also used the system to screen out several novel anti-cancer small molecules from the National Cancer Institute's Diversity Library, and one of the compounds continuously and efficiently inducesprotein expression of the tumor suppressor gene RhoB in various cancer cells such as lung cancer, brain tumor, and rhabdomyosarcoma,and inhibits cancer cell proliferation, migration and induces apoptosis, without too much cytotoxicity.
Based on this discovery, Dr. Zhang Chunyu scientifically allocated small molecule nutrients of plant to protect normal cells and prolong their lifespan while inhibiting cancer cells proliferation, migration, and causing them apoptosis. This leading scientific research proves that dietary intervention can not only effectively inhibit skin inflammation, delay skin aging, but also significantly reduce the occurrence and development of lung cancerinduced by tobacco carcinogens.
ANew Dietary Supplement of Anti-cancer RejuvenationtoBenefit Mankind
Based on the above research results, Dr. Zhang Chunyu and his team successfully developed a dietary supplement containing key components of Ceramide, Curcumin, and EGCG, and submitted applications for related patents to the U.S. Patent and Trademark Office. At the same time, in order to speed up the transformation of results, Dr. Zhang Chunyu established SanuLife Inc in Maryland, USA. Focusing on research and development of science-based biopharmaceuticals and products boostinghealth managementand self-cultivation performance, SanuLife aims tointegratehigh-quality resources and forward-looking technologies to provide one-stop, customizedand intelligenthealth servicesthat precisely address thephysical and mentalneeds of users.
The ROVIDIUM series products of SanuLifeInc are scientific, safe, and effective dietary supplementsthatextractnatural components in plantsand harness the down-regulatedRhoB during transformation from normal cells to cancer cells. ROVIDIUMalso gives play tothe synergybetween RhoB with longevity transcriptional factor Nrf2, which drives expression of endogenous antioxidant, anti-inflammatory and anti-fibrotic genes, through another tumor suppressor gene p21 induced by RhoB. The products restoreendogenous RhoB expression, which is continuously observed to be epigenetically down-regulated during pulmonary aging, skeletal muscle decline, and tumorigenesis, and activate Nrf2 through p21 to stabilize the genomeandprotect cells fromcarcinogenesis, which aims to help delay aging, prevent cancer and increase healthspan.
责编：汉网
